[Survival rate among children with acute lymphoblastic leukemia based on their relapse status in Shiraz Shahid Faghihi hospital during 2004-9]

Relapse in leukemic patients is considered as a major cause of treatment failure and a decrease in patient survival rate. This study was conducted to determine the survival rate of patients with acute lymphoblastic leukemia [ALL] and acute myeloid leukemia [AML] based on their relapse status. This retrospective cohort study was performed on a total of 243 cases of leukemia aged less than 15 years in Shiraz Shahid Faghihi hospital. Data were analyzed using Kaplan-Meier method, log-rank test and Cox regression model. The 1-and 5-year survival rates for patients without relapsed leukemia were 96.9 and 76.9% and for relapsed leukemia were 82.4 and 28.6%, respectively. Therefore, there was a significant relationship between the relapse occurrence and survival rate among the patients [P=0.001]. The relapse occurrence is one of the main effective factors in survival rate of leukemic patients; a five-year survival rate in the patients is less than 30 percent in this center

[Trend of incidence rate for female genital cancers based on cancer registry data in Fars province during 2003-2009]

Genital cancers are the second most common cancer among women [after breast cancer] in some countries. The aim of this study was to determine the trend of the age-standardized incidence rates for female genital cancers in Fars province during 2003-2009. In this descriptive study, using Fars province cancer registry data, the crude incidence rate per 100,000 people and the age-standardized incidence rates were calculated through direct standardization method and using the world standard population. In addition, to evaluate changes in incidence rate trend, the Cochran-Armitage linear trend test was used. Results showed that ovarian cancer was estimated as the most common cancer of female genital cancers. Age-standardized incidence rate of all female genital cancers during 2003-2009 were 3.7, 3.77, 5.52, 6.62, 9.75 and 12.4 cases per 100,000 people, respectively. It seems that the incidence rate of female genital cancers in Fars province is the same as the other regions in Iran which exhibits an ascending trend

Graft survival rate of renal transplantation: a single center experience, [1999- 2009]

Renal transplantation is the best option for treatment of the end-stage renal diseases and has more advantages than dialysis. The objective of this study is to determine the ten-year graft survival rate of renal transplantation and its associated factors in patients who have been transplanted from March 1999 to March 2009 in Nemazee Hospital Transplantation Center. This is a historical cohort study of 1356 renal transplantation carried out during 1999 to 2009. Kaplan-Meier method was used to determine the survival rate, log rank test to compare survival curves, and Cox regression model to determine hazard ratios and for modeling of variables affecting survival. The 1, 3, 5, 7 and 10 years graft survival rates were 96.6, 93.7, 88.9, 87.1 and 85.5 percent, respectively. Cox regression model revealed that the donor source and creatinine level at discharge were effective factors in graft survival rate in renal transplantation. Our study showed that 10 year graft survival rate for renal transplantation in Nemazee Hospital Transplantation Center was 85.5% and graft survival rate was significantly related to recipients and donor's age, donor source and creatinine level at discharge. Our experience in renal transplantation survival rate indicates a success rate comparable to those noted in other reports

[Graft survival rate of renal transplantation in diabetic patients, Namazi hospital transplant center, Shiraz, Iran [1999-2009]]

In many countries around the world, diabetic nephropathy is the most common causes of renal transplantation and dialysis. One third of diabetic patients suffer from kidney diseases which, in turn, considerably increase mortality rates and treatment costs. The aim of this study was to compare graft survival rate in diabetic and non-diabetic patients in the Shiraz Namazi Hospital Transplant Center, during the years 1999 to 2009. This study was a retrospective cohort study that investigated graft survival rate among diabetic patients who had undergone kidney transplant and compared it with that of non-diabetic patients, in the Transplant Center of Shirza Namazi Hospital. The Kaplan-Meier method was used to calculate the survival rate and Log-rank test was applied to compare survival curves. Furthermore, to model the factors affecting survival rate, Cox proportional hazard model was implemented. The results of the study revealed that the average follow-up period of patients was 48.15 +/- 31.05 [range: 3.07- 118.03] months. The estimated 9-year graft survival rates among diabetic and non-diabetic patients were 84.2% and 85.7%, respectively. Moreover, using Cox proportional hazard model, it was found that the age of a donor <40 years, is an effective factor for higher graft survival rate in diabetic patients. Based on the results of this study, we observed that there was no significant difference between kidney transplant survival rate in diabetic and non diabetic patients. This treatment method can hence be a good option for patients with diabetic nephropathy

[10-year graft survival analysis of renal transplantation and factors affecting it in patients transplanted from live donor in Shiraz transplant research center during 1999-2009]

Background and Aims: Renal transplantation is the best therapeutic option for End Stage Renal Disease [ESRD]. The aim of this study was to determine the graft survival rate of renal transplantation in patients who have been transplanted from live donor in Shiraz Transplant Research Center, Shiraz, Iran

Methods: In a survival analysis study, organ survival rate after kidney transplantation from live donor was determined in 843 patients being transplanted in Shiraz Transplant Research Center, Iran during a period of 10 years [March 1999 to March 2009]. Kaplan-Meier method was used to determine the survival rate, Logrank test was used to compare survival curves and Cox proportional hazard model was used for multivariate analysis

Results: Mean follow-up period [+/- Standard deviation] was 53.07+/-34.6 months. Allograft survival rates at 1, 3, 5, 7 and 10 years after kidney transplantation were found to be 98.3%, 96.4%, 92.5%, 90.8% and 89.2%, respectively. Using Cox proportional hazard model, age of donor and creatinine level at discharge showed significant relationships with survival rate of renal allograft

Conclusion: The 10- year graft survival rate of renal transplantation from live donor in this center is 89.2% which in comparison with reports from large centers of transplantation it is satisfactory